Will Rodman (James Franco) a scientist at biotechnology company Gen-Sys, is testing viral-based drug "ALZ-112' on chimpanzees to find a cure for brain ailments such as Alzheimer's disease. The drug is given to a chimpanzee, Bright Eyes, greatly increasing her intelligence, but she is forced from her cage, goes on a rampage, and is killed. Will's boss Steven Jacobs (David Oyelowo) terminates the project and orders chimp handler Robert Franklin (Tyler Labine) to euthanize the chimps. After doing as ordered, Franklin discovers that Bright Eyes had recently given birth and convinces Will to save the baby chimp's life by taking him home temporarily. Will's father Charles (John Lithgow), who is suffering Alzheimer's disease, names the chimp "Caesar." Will learns that Caesar (Andy Serkis) has inherited his mother's high intelligence and decides to raise him, working from home and observing his behavior in hopes that he can get the project restarted. Three years later, Will introduces Caesar to the redwood forest at Muir Woods National Monument. Meanwhile, with Charles' condition rapidly deteriorating, Will treats him with ALZ-112 and he is restored to better-than-original cognitive ability.
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